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Viagra (made by Pfizer) is used for the treatment of male impotency. The active ingredient in Viagra is a specific inhibitor of phosphodiesterase 5. Phosphodiesterase 5 (PDE5) cleaves the ring form of cyclic GMP ( cGMP ) a cellular second messenger similar to cAMP . The inhibition of the phosphodiesterase allows for the persistence of cGMP which promotes the effects of cGMP production. In this case, it allows for increased blood flow into the penis which may result in an erection.

Normally, sexual stimulation in the male is followed by release of nitric oxide (NO) in the corpus cavernosum of the penis. NO activates the enzyme guanylate cyclase in the smooth muscle cells which allows for the relaxation of the penile arteries and an increase flow of blood into the penile cavity. The effect of Viagra is to allow the accumulation of cGMP by inhibiting the phosphodiesterase action which tends to magnify the effect of NO release.

Clearly, the mechanism of penile erection is a case of when NO means yes.

One of the curious side effects of Viagra is an effect on the visual discrimination of certain colors. This appears to be due to the reduced affinity of the drug for the phosphodiesterase enzyme found in the retina (PDE6). Viagra has an even more reduced affinity for PDE3 which is critical since PDE3 is active in heart muscle cells.



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Information on this site is provided for informational purposes and isn’t meant to substitute for the advice provided by your own physician or other medical professional. You shouldn’t use the info contained herein for diagnosing or treating a health problem or disease, or prescribing any medication. Information on this site isn’t intended to diagnose, treat, cure, or prevent any disease.

NOTE: All trademarks used on this site and brand names are the property of the respective trademark holders. We are not associated with these trademark holder companies in any sense and has never been affiliated with Pfizer, except in the fact that we make it possible for consumers to order certain Generic Drugs by internet.


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